The funders had no role in study design, data collection and analysis, or preparation of the manuscript. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: This project was funded by Technology Foundation STW, Food Allergy Foundation, Siemens Healthcare Diagnostics, HAL Allergy, Intersnack the Netherlands B.V., ALK-Abello B.V., and The Netherlands Anaphylaxis Network. Received: NovemAccepted: FebruPublished: March 11, 2016Ĭopyright: © 2016 van der Valk et al. PLoS ONE 11(3):Įditor: Jane Hoppin, North Carolina State University, UNITED STATES (2016) Multicentre Double-Blind Placebo-Controlled Food Challenge Study in Children Sensitised to Cashew Nut. A total of 36% (49/137) of the children experienced an anaphylactic reaction and 6% (8/137) of the children were treated with epinephrine.Ĭitation: van der Valk JPM, Gerth van Wijk R, Dubois AEJ, de Groot H, Reitsma M, Vlieg-Boerstra B, et al. Children most frequently had gastro-intestinal symptoms, followed by oral allergy and skin symptoms. The study showed that 137 (76.5%) of the sensitised children suspected of allergy to cashew nut had a positive double-blind placebo-controlled food challenge test, with 46% (63) manifesting subjective symptoms to the lowest dose of 1 mg cashew nut protein and 11% (15) developing objective symptoms to the lowest dose. The children underwent a double-blind placebo-controlled food challenge test with cashew nut during the second and third visits. During the first visit, the medical history was evaluated, physical examinations were conducted, blood samples were drawn and skin prick tests were performed. The study included three clinical visits and a telephone consultation. Sensitised children who could tolerate cashew nuts were excluded. A total of 179 children were included (median age 9.0 years range 2–17 years) with cashew nut sensitisation and a clinical history of reactions to cashew nuts or unknown exposure.
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